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Global NMN clinical trial report-Chuanyu
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Global NMN clinical trial report-Chuanyu

Global NMN clinical trial reports

There are a large number of documents from all over the world showing the anti-aging effects of NMN, but the content is really rich. We hope that the integration will allow everyone to have a deeper understanding of this biotechnology product. NMN is no longer a plaything of celebrities, but is really changing human beings every day. A supplement for life is a body supplement with scientific substance that can change the future.

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August 2022 Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes

August 2022 Nicotinamide mononucleotide ameliorates DNFB-induced atopic dermatitis-like symptoms in mice by blocking activation of ROS-mediated JAK2/STAT5 signaling pathway

July 2022 Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE

July 2022 Combination of nicotinamide mononucleotide and troxerutin induces full protection against doxorubicin-induced cardiotoxicity by modulating mitochondrial biogenesis and inflammatory response

July 2022 Administration of nicotinamide mononucleotide improves oocyte quality of obese mice

July 2022 Nicotinamide Mononucleotide and Coenzyme Q10 Protects Fibroblast Senescence Induced by Particulate Matter Preconditioned Mast Cells

June 2022 Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice

June 2022 Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis

June 2022 Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis

June 2022 Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment

June 2022 Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress

June 2022 Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury

June 2022 Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells

June 2022 Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling

May 2022 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

May 2022 Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver

May 2022 Distribution of Nicotinamide Mononucleotide After Intravenous Injection in Normal and Ischemic Stroke Mice

May 2022 Nicotinamide mononucleotide ameliorates acute lung injury by inducing mitonuclear protein imbalance and activating the UPR mt

May 2022 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

April 2022 NAD + Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy

April 2022 NAD +-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice

April 2022 Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency

April 2022 Treatment of SARS-CoV-2-induced pneumonia with NAD + and NMN in two mouse models

April 2022 Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

April 2022 The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions

April 2022 NAD + Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy

April 2022 Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress

April 2022 Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes

April 2022 NAD+ ameliorates endotoxin-induced acute kidney injury in a sirtuin1 dependent manner via GSK-3 β /Nrf2 signaling pathway

April 2022 Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment

April 2022 Intestinal Epithelial NAD+ Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice

April 2022 NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

April 2022 NAD supplementation improves mitochondrial performance of cardiolipin mutants

March 2022 Antioxidant effect of nicotinamide mononucleotide in tendinopathy

March 2022 Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

March 2022 Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy

March 2022 Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1/Nrf2/HO-1 pathway

February 2022 Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

February 2022 PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

January 2022 Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns

January 2022 NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury

December 2021 Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats

November 2021 Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

November 2021 The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

November 2021 NAD + Metabolism in Cardiac Health, Aging, and Disease

November 2021 Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice

October 2021β -Nicotinamide Mononucleotide (NMN) Administered by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

October 2021 Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?

July 2021 NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota

July 2021 Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

July 2021 Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

June 2021 The new insight into extracellular NAD + degradation-the contribution of CD38 and CD73 in calcific aortic valve disease

June 2021 Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

June 2021 Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

June 2021 Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation

June 2021 Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice

May 2021 Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

April 2021 Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats

March 2021 Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

March 2021 Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

February 2021 Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether

February 2021 Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System

January 2021 Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration

January 2021 Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE 2 degradation

December 2020 Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment

December 2020 NMN reduces the chance and severity of novel coronavirus infection by improving mitochondrial dysfunction

November 2020 NMN can reverse the loss of protein homeostasis and reduce kidney aging in animal experiments

November 2020 NMN could be a new generation treatment to prevent liver fibrosis in animals

October 2020 NMN can effectively enhance the healing and neurological rehabilitation of corneal epithelial damage in diabetic animals

October 2020 NMN can reverse systolic dysfunction in aged hearts in animal experiments

August 2020 NMN can reverse cardiovascular endothelial cell dysfunction in animals

August 2020 NMN can reverse oocyte aging in animals and theoretically improve human female infertility

August 2020 NMN can effectively inhibit and reduce oocyte DNA mutations in animals and is expected to become one of the treatment options for female infertility.

July 2020 NMN can treat osteoporosis caused by taking steroids in animals

July 2020 NMN can effectively reduce brain cell damage caused by severe hypoglycemia in animals

July 2020 NMN may have therapeutic effect on age-related macular degeneration in humans

June 2020 Exploring the potential of NMN to treat neuromedical diseases

May 2020 NMN has a preventive effect on brain amnesia and dementia in animals due to diabetes

April 2020 Explore the feasibility of NMN treatment for various diseases

April 2020 NMN can effectively reduce corneal endothelial cell apoptosis induced by UVB irradiation

April 2020 NMN can promote neurovascular regeneration in aged animals

April 2020 NMN can reduce metabolic diseases caused by maternal overweight in animals

March 2020 NMN can effectively improve intracranial hemorrhage in animals and protect brain tissue

March 2020 NMN can treat acute brain injury and neurodegenerative diseases in animals

February 2020 NMN effectively treats depression in animals

February 2020 NMN rejuvenates oocyte quality in aging animals, leading to restoration of fertility

February 2020 NMN can effectively prevent corneal endothelial cell apoptosis in animals

February 2020 NMN rescues neurovascular function, increases cerebral blood flow and improves performance on cognitive tasks in animals

January 2020 NMN can improve cardiomyocyte hypertrophy caused by excessive stress in animals

The following is in progress / Human clinical trials with reported results :

November 2019 No adverse reactions after taking NMN in human clinical trials

May 2019 summarizes the efficacy of NMN on metabolic diseases and discusses its human clinical trials

January 2019 to explore the therapeutic effect of NMN on protecting the heart , preventing diabetes , preventing cognitive impairment , and complications caused by obesity.

Effects of taking NMN on cardiovascular and metabolic diseases in humans in July 2017

In March 2016 , Keio University in Japan and Washington University in St. Louis in the United States began the first phase of human clinical trials on NMN.

Many doctors and scientists around the world are beginning to study NMN Conduct human clinical studies. From the analysis of many known clinical effects in animals, scientists believe that NMN It is optimistic and positive about the effectiveness of human health maintenance and anti-aging. It is believed that the time for human clinical results to be available is not far away.

The author is a registered doctor, and I have no doubt about the effectiveness of NMN in helping human health and delaying human aging. My family and I have been taking NMN every day for quite some time. I also recommend everyone to start taking it today.

December 2019 Application of NMN in chronic alcoholic liver disease in animals

December 2019 NMN can effectively reduce memory decline caused by elderly animals

December 2019 NMN has therapeutic effects on muscle aging in animals

October 2019 NMN is effective in treating acute myocardial ischemia in animals

October 2019 NMN significantly helps regenerate cerebral vascular cells in aged animals

August 2019 NMN can effectively reduce vascular aging in animals

August 2019 NMN can reduce corneal epithelial cell apoptosis in animals

August 2019 The effect of NMN on animal mitochondria can improve pathophysiological stress disorders

June 2019 NMN can effectively maintain telomere length and has therapeutic effects on liver fibrosis

May 2019 NMN helps animals with cerebrovascular diseases and improves brain power

April 2019 NMN reaffirmed to be helpful in diabetic nephropathy in animals

In April 2019 , NMN enhanced the efficacy of mesenchymal stem cells in bone hyperplasia in animals.

In March 2019 , it was recommended that NMN should be included as one of the rigorous regimens for the treatment of human cardiovascular disease in aging.

March 2019 NMN may have therapeutic effect on osteoporosis in animals or humans

March 2019 NMN may be an effective future treatment for diabetic nephropathy in animals

March 2019 Explore the principles of NMN in anti-aging and treatment of ischemic conditions

February 2019 NMN has therapeutic effect on mitochondrial diseases in animals

January 2019 NMN has great potential to treat neurodegenerative diseases

November 2018 NMN increases cognitive abilities in animal brains

October 2018 NMN can effectively improve osteoporosis caused by aluminum in animals

October 2018 NMN can effectively protect intervertebral disc degeneration in animals

September 2018 NMN greatly increases animals’ chances of survival in hemorrhagic shock

August 2018 NMN has cardioprotective effects in animals

June 2018 NMN can effectively improve the aging of animal retinal epidermal tissue

March 2018 NMN can effectively increase blood flow to various organs in animals

December 2017 NMN/Nicotinamide Riboside may be effective in human cognitive impairment ( commonly known as Alzheimer’s disease )

November 2017 NMN is effective in treating glucose intolerance and fat loss in animals

November 2017 NMN is effective in treating diabetic nephropathy in animals

November 2017 NMN has therapeutic effect on heart failure in animals

November 2017 NMN can effectively reduce complications caused by cerebral vascular embolism treatment in animals

August 2017 NMN/Nicotinamide Riboside can effectively reduce the aging caused by animal muscle metabolism

August 2017 NMN can effectively protect animals from acute kidney injury

July 2017 NMN is effective in treating large intestinal degeneration in animals

July 2017 NMN can effectively improve heart function in animals with cardiomyopathy

April 2017 NMN can effectively reduce cerebral edema and brain cell death in animals with hemorrhagic stroke

April 2017 NMN can effectively improve various pathological effects of cognitive impairment in animals ( commonly known as Alzheimer’s disease )

March 2017 NMN can effectively protect retinopathy in animals

December 2016 NMN can effectively improve the physical fitness, metabolism and vision of animals when they are old, and can reduce body weight, blood lipids and diabetes

November 2016 NMN can strongly protect animals from damage caused by local cerebral ischemia

In August 2016 , NMN can effectively improve various metabolic indicators of obese animals, and the effect is comparable to that of exercise.

In July 2016 , NMN has good curative effect on cognitive impairment ( senile dementia ) in animals.

June 2016 NMN can reverse vascular aging in animals

In July 2014 , NMN was effective in treating Parkinson’s disease in animals.

June 2014 NMN has protective effects on cardiac ischemia in animals

October 2011 NMN can effectively improve type 2 diabetes in animals due to aging or diet.

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