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全球NMN 的臨床實驗報告 - 川御
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全球NMN 的臨床實驗報告 - 川御

全球NMN 的臨床實驗報告

全球各地都均有大量文獻表示NMN 的抗衰老功效,但內容實在非常豐富,我們希望整合讓大家可以更深了解這個生物科技產品,NMN 不再是名人的玩物,而是真的每天都在改變人類生命的一個補充品,是一個可以改變未來的有科學實體的身體補充品。

了解更多:
20228 Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes

20228 Nicotinamide mononucleotide ameliorates DNFB-induced atopic dermatitis-like symptoms in mice by blocking activation of ROS-mediated JAK2/STAT5 signaling pathway

20227 Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE

20227 Combination of nicotinamide mononucleotide and troxerutin induces full protection against doxorubicin-induced cardiotoxicity by modulating mitochondrial biogenesis and inflammatory response

20227 Administration of nicotinamide mononucleotide improves oocyte quality of obese mice

20227 Nicotinamide Mononucleotide and Coenzyme Q10 Protects Fibroblast Senescence Induced by Particulate Matter Preconditioned Mast Cells

20226 Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice

20226 Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis

20226 Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis

20226 Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment

20226 Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress

20226 Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury

20226 Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells

20226 Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling

20225 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

20225 Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver

20225 Distribution of Nicotinamide Mononucleotide After Intravenous Injection in Normal and Ischemic Stroke Mice

20225 Nicotinamide mononucleotide ameliorates acute lung injury by inducing mitonuclear protein imbalance and activating the UPR mt

20225 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

20224 NAD + Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy

20224 NAD +-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice

20224 Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency

20224 Treatment of SARS-CoV-2-induced pneumonia with NAD + and NMN in two mouse models

20224 Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

20224 The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions

20224 NAD + Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy

20224 Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress

20224 Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes

20224 NAD+ ameliorates endotoxin-induced acute kidney injury in a sirtuin1dependent manner via GSK-3β/Nrf2 signalling pathway

20224 Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment

20224 Intestinal Epithelial NAD+ Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice

20224 NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

20224 NAD supplementation improves mitochondrial performance of cardiolipin mutants

20223 Antioxidant effect of nicotinamide mononucleotide in tendinopathy

20223 Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

20223 Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy

20223 Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1/Nrf2/HO-1 pathway

20222 Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

20222 PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

20221 Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns

20221 NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury

202112 Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats

202111 Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

202111 The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

202111 NAD + Metabolism in Cardiac Health, Aging, and Disease

202111 Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice

202110月 β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

202110 Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?

20217 NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota

20217 Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

20217 Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

20216 The new insight into extracellular NAD + degradation-the contribution of CD38 and CD73 in calcific aortic valve disease

20216 Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

20216 Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

20216 Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation

20216 Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice

20215 Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

20214 Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats

20213 Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

20213 Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

20212 Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether

20212 Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System

20211 Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration

20211 Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE 2 degradation

202012 Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment

202012 NMN透過改善粒線體功能失常,減低感染新型冠狀病毒的機會及嚴重性

202011 NMN在動物實驗能逆轉蛋白質穩態的喪失,減低腎臟衰老

202011 NMN在動物能成為預防肝纖維化的新一代治療

202010 NMN能有效增強糖尿動物角膜上皮破損的癒合及神經康復

202010 NMN在動物實驗能逆轉年老心臟的收縮功能障礙

20208 NMN能逆轉動物心血管內皮細胞功能失調

20208 NMN能逆轉動物的卵母細胞衰老 理論上能改善人類女性不育

20208 NMN在動物能有效抑制及減少卵母細胞DNA異變 有望成為女性不育治療方案之一育

20207 NMN在動物能治療服用類固醇所導致的骨質疏鬆

20207 NMN能有效減低動物嚴重低血糖所引致的腦細胞受損

20207 NMN可能對人類老年性黃斑部病變有療效

20206月 探討NMN治療神經醫學疾病的可能性

20205 NMN對動物因糖尿病腦部失憶及失智有預防療效

20204月 探討NMN對各種不同疾病的治療可行性

20204 NMN能有效降低UVB照射引發的角膜內皮細胞凋亡

20204 NMN在年邁動物能促進神經血管再生

20204 NMN在動物能減輕母體過重引致的代謝疾病

20203 NMN能有效改善動物顱內出血問題並保護腦組織

20203 NMN在動物能治療急性腦損傷和神經退行性疾病

20202 NMN在動物能有效地治療抑鬱症

20202 NMN可使衰老動物的卵母細胞質量恢復活力,從而導致生育力恢復

20202 NMN對動物能有效防止角膜內皮細胞凋亡

20202 NMN對動物能搶救神經血管功能,增加腦血流量並改善認知任務的表現

20201 NMN在動物能改善因承受過大壓力而引致的心肌細胞肥大

以下是正在進行中/ 已研究發報成果的人類臨床實驗 

201911 NMN人類臨床實驗服用後沒有不良反應

20195月 總結NMN對代謝疾病的療效及討論其人類臨床實驗

20191月 探討NMN對保護心臟,預防糖尿,預防認知障礙,及肥胖引起的併發症等病症的治療效果

20177月人類服用NMN對心血管及代謝症的影響

20163月日本慶應義塾大学聯同美國聖路易斯華盛頓大學開始了第一期關於NMN人類臨床實驗

全球各地已有不少醫生及科學家正開始對 NMN 進行人類臨床研究。從多次已知的動物臨床效果分析,科學家都認為 NMN 對於人類維護健康、對抗衰老的成效是樂觀和正面的。相信人類臨床結果面世的時間已不遠矣。

筆者是註冊醫生,NMN對人類健康的幫助和延遲人類衰老的成效 我深信不疑。我和家人每天服用NMN已有相當的時間。我也建議大家今天起開始服用。

201912 NMN在動物慢性酒精性肝病的應用

201912 NMN能有效減低年邁動物所帶來的記憶衰退

201912 NMN對動物的肌肉老化有療效

201910 NMN對動物急性心肌缺血有療效

201910 NMN對年邁動物腦血管細胞再生有明顯幫助

20198 NMN能有效減低動物血管老化

20198 NMN在動物能減低眼角膜表皮細胞凋亡

20198 NMN對動物線粒體的影響能改善病理生理性壓力病症

20196 NMN能有效維持端粒長度並對肝臟纖維化有療效

20195NMN對動物腦血管疾病有幫助並能改善腦力

20194 NMN再被證實在動物糖尿腎病有幫助

20194NMN對動物增進間充質幹細胞對骨質增生的療效

20193月建議NMN應被列為治療人類心血管病老化的嚴謹方案之一

20193NMN可能對動物或人類骨質疏鬆有療效

20193NMN可能是動物糖尿腎病未來有效的治療

20193月探討NMN對抗衰老及缺血狀況治療的原理

20192NMN對動物線粒體疾病有療效

20191NMN極有潛力醫治神經退化性疾病

201811NMN對動物腦部增加認知能力

201810NMN能有效改善動物鋁質導致的骨質疏鬆病

201810NMN在動物能有效保護椎間盤的退化

20189NMN大大增加了動物在失血性休克的存活機會

20188NMN對動物有保護心臟的作用

20186NMN能有效改善動物視網膜表皮組織老化

20183NMN能有效對動物增加各處器官的血流量

201712NMN/Nicotinamide Riboside可能對人類認知障礙症(俗稱老人痴呆)有療效

201711NMN對動物葡萄糖耐受不良及減脂有療效

201711NMN對動物糖尿病腎病有療效

201711NMN對動物心臟衰竭有療效

201711NMN能有效減低對動物腦血管栓塞治療所引起的併發症

20178NMN/Nicotinamide Riboside能有效減低對動物肌肉新陳代謝引致的衰老

20178NMN能有效保護動物免受急性腎損傷的傷害

20177NMN對動物大腸退化有療效

20177NMN能有效改善動物心肌症的心臟功能

20174NMN能有效減低對動物出血性中風的腦水腫和腦細胞死亡

20174NMN能有效改善動物認知障礙症(俗稱老人痴呆)的各種病理影響

20173NMN能有效在動物保護視網膜病變

201612NMN能有效改善動物年老時的體能,新陳代謝及視力,並能減低體重,血脂及糖尿病

201611NMN能強烈保護動物的局部性腦缺血帶來的傷害

20168NMN能有效改善肥胖動物的各種代謝指標,效果可比美做運動

20167NMN對動物認知障礙(老人癡呆)有良好療效

20166NMN能逆轉動物血管老化

20147NMN對動物柏金遜病有療效

20146NMN對動物心臟缺血有保護作用

201110 NMN能有效改善動物因年老或飲食誘發的二型糖尿

 

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